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Here's something I said to Shimmering Brony regarding cartoon characters in M.U.G.E.N.:
With cartoon characters, it all depends on you how good you make them. If you make them with source accurate material like Warner's characters and The None's Beavis and Butthead, then you got a good character. But if it's like the first version of WlanmaniaX's Rocko or Beanfan's characters, then it's not good.
It's good to incorporate original ideas into cartoon charcters as well. WlanmaniaX's Danger Mouse had him use ray guns, grenades, and a rocket launcher. The only weapon DM ever actually carried in the show was a pistol, and it was only shown in one episode.
And BTW, certain characters fit, others don't. Here's an example:
Sunset Shimmer having firebending powers and athletic abilities makes her a good fighter. But for Fluttershy, she's very kind-hearted and wouldn't hurt anybody, so she's not a good idea for a M.U.G.E.N. fighter.
The main thing that matters when you're making a character from a cartoon or anime is that you give them moves that they have used in their source material (Panty's gun, Vicky's chainsaw and other weapons, Stocking's swords, etc.), but it's okay to give them moves that you thought up of as well.